RunKeeper for iOS gets new social feed and leaderboard

The fitness app RunKeeper already lets you check stats on your smartwatch, but what is activity tracking without a public shaming social component? Starting today, the iOS version of the app includes a new feed for viewing your friends' logged workouts along with your own, complete with the ability to comment on and "like" activities à la Facebook. Version 3.5 also adds a leaderboard, which ranks how you stack up against your pals. Hardly earth-shattering features, but the competitive bent might motivate you to push through an extra mile or two. Grab the update via the source link below.

Filed under: Software

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Source: RunKeeper (iTunes)

Source: http://www.engadget.com/2013/06/11/runkeeper-for-ios-new-social-feed-leaderboard/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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New therapy target for kids' fever-induced seizures

Public release date: 11-Jun-2013
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Contact: Marla Paul
marla-paul@northwestern.edu
312-503-8928
Northwestern University

Common drug reduces febrile seizures

CHICAGO - Fever-induced childhood seizures, known as febrile seizures, can be terrifying for parents to witness. The full-body convulsions, which mostly affect children six months to five years old, can last from mere seconds up to more than 40 minutes. Currently, children are not treated with daily anticonvulsant medication to prevent these seizures even when they recur repeatedly because toxic side effects of existing treatments outweigh potential benefits.

While scientists know these seizures typically occur when a fever is above 100.4 degrees Fahrenheit (38 degrees Celsius), the exact mechanism at work has been unclear.

Now, in a new study appearing in the June 12, 2013 issue of The Journal of Neuroscience, a team of Northwestern Medicine researchers has identified a new key factor in the generation of febrile seizures, leading to a new therapeutic target for humans. The team further found that nimodipine, a commonly available L-type calcium-channel blocker, dramatically reduced the incidence and duration of febrile seizures in animals.

"Until now, most scientists believed L-type calcium channels, pores in the membrane that allow calcium into cells, were not engaged in the initiation of the brain electrical activity," said the study's lead author Marco Martina, MD, associate professor in physiology at Northwestern University Feinberg School of Medicine. "We show that the activation of these channels, which are temperature sensitive, actually drives the electrical activity, not just follows it. As such, these channels may play a key role in seizure associated with high body temperature. Consequently, we can develop better treatments for toddlers and reduce the risk of negative outcomes."

Febrile seizures affect about five percent of children in the United States and are mostly benign, but do carry a risk of negative long-term consequences on brain development.

In this study, the Northwestern team used electrical recordings of the hippocampus of rats to determine that temperature-sensitive L-type calcium channels in triangle-shaped neurons, which are the major neuronal cell type of the brain cortex, play a major role in febrile seizures. This observation provides an alternative therapeutic target for febrile seizures that is distinct from current epilepsy drug therapy, which commonly focuses on blocking sodium channels.

Once the team identified L-type calcium channels in neurons as the likely culprit, scientists took the finding one step further to test their hypothesis, administering the calcium channel blocker nimodipine in an animal model as a treatment for febrile seizures. The results were striking: nimodipine dramatically reduced both the incidence and duration of febrile seizures in rat pups.

"The good news is that we already have many FDA-approved drugs that block L-type calcium channel," says Martina. "Therefore if proven effective in clinical trials, this could be an important advance in clinical care. Because L-type calcium channel blockers such as nimodipine are safe drugs, every toddler with febrile seizures can potentially be treated to stop or prevent seizures triggered by high fever and reduce the risk of long term neurological consequences of uncontrolled recurrent or prolonged febrile seizures."

Sookyong Koh, MD, associate professor in pediatricsneurology at Feinberg, and co-author on the paper, adds that these findings could be helpful for one group of children in particular: those with genetic epilepsy syndromes whose seizures are triggered by fever, and for whom most anticonvulsants acting on sodium channels are harmful.

###

Funding for this study was provided by the Epilepsy Foundation, National Institutes of Health's National Institute of Neurological Disorders and Stroke (NINDS) grants NS064091 and NS073768, Ann & Robert H. Lurie Children's Hospital of Chicago, and Northwestern University Feinberg School of Medicine Department of Pediatrics. First author Daniel Radzicki is a graduate student in Northwestern University's Interdepartmental Neuroscience Program.

---

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 11-Jun-2013
[ | E-mail | Share ]

Contact: Marla Paul
marla-paul@northwestern.edu
312-503-8928
Northwestern University

Common drug reduces febrile seizures

CHICAGO - Fever-induced childhood seizures, known as febrile seizures, can be terrifying for parents to witness. The full-body convulsions, which mostly affect children six months to five years old, can last from mere seconds up to more than 40 minutes. Currently, children are not treated with daily anticonvulsant medication to prevent these seizures even when they recur repeatedly because toxic side effects of existing treatments outweigh potential benefits.

While scientists know these seizures typically occur when a fever is above 100.4 degrees Fahrenheit (38 degrees Celsius), the exact mechanism at work has been unclear.

Now, in a new study appearing in the June 12, 2013 issue of The Journal of Neuroscience, a team of Northwestern Medicine researchers has identified a new key factor in the generation of febrile seizures, leading to a new therapeutic target for humans. The team further found that nimodipine, a commonly available L-type calcium-channel blocker, dramatically reduced the incidence and duration of febrile seizures in animals.

"Until now, most scientists believed L-type calcium channels, pores in the membrane that allow calcium into cells, were not engaged in the initiation of the brain electrical activity," said the study's lead author Marco Martina, MD, associate professor in physiology at Northwestern University Feinberg School of Medicine. "We show that the activation of these channels, which are temperature sensitive, actually drives the electrical activity, not just follows it. As such, these channels may play a key role in seizure associated with high body temperature. Consequently, we can develop better treatments for toddlers and reduce the risk of negative outcomes."

Febrile seizures affect about five percent of children in the United States and are mostly benign, but do carry a risk of negative long-term consequences on brain development.

In this study, the Northwestern team used electrical recordings of the hippocampus of rats to determine that temperature-sensitive L-type calcium channels in triangle-shaped neurons, which are the major neuronal cell type of the brain cortex, play a major role in febrile seizures. This observation provides an alternative therapeutic target for febrile seizures that is distinct from current epilepsy drug therapy, which commonly focuses on blocking sodium channels.

Once the team identified L-type calcium channels in neurons as the likely culprit, scientists took the finding one step further to test their hypothesis, administering the calcium channel blocker nimodipine in an animal model as a treatment for febrile seizures. The results were striking: nimodipine dramatically reduced both the incidence and duration of febrile seizures in rat pups.

"The good news is that we already have many FDA-approved drugs that block L-type calcium channel," says Martina. "Therefore if proven effective in clinical trials, this could be an important advance in clinical care. Because L-type calcium channel blockers such as nimodipine are safe drugs, every toddler with febrile seizures can potentially be treated to stop or prevent seizures triggered by high fever and reduce the risk of long term neurological consequences of uncontrolled recurrent or prolonged febrile seizures."

Sookyong Koh, MD, associate professor in pediatricsneurology at Feinberg, and co-author on the paper, adds that these findings could be helpful for one group of children in particular: those with genetic epilepsy syndromes whose seizures are triggered by fever, and for whom most anticonvulsants acting on sodium channels are harmful.

###

Funding for this study was provided by the Epilepsy Foundation, National Institutes of Health's National Institute of Neurological Disorders and Stroke (NINDS) grants NS064091 and NS073768, Ann & Robert H. Lurie Children's Hospital of Chicago, and Northwestern University Feinberg School of Medicine Department of Pediatrics. First author Daniel Radzicki is a graduate student in Northwestern University's Interdepartmental Neuroscience Program.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-06/nu-ntt061113.php

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How to share the iTunes library on your Mac or PC on any WiFi network

If you use iTunes to manage your music collection, you can easily share it across any WiFi network where friends and family can stream and listen to your music. It's a great way to discover new music that requires no cables or transferring of files.

Follow along and we'll show you how.

Before continuing, it's worth noting that if both computers aren't authorized on the same iTunes account, you won't be able to listen to any content purchased from iTunes, only media acquired other ways. If both computers are authorized on the same iTunes account and have Home Sharing enabled, you should be able to play back any music. To enable Home Sharing, just go to File followed by Home Sharing and Enable Home Sharing. You'll need to do this with any computers you'd like iTunes purchased content to be played on. You can authorize up to 5 computers on any single iTunes account.

1. Launch iTunes on your Mac or PC.
2. Now in the top navigation, click on iTunes and then Preferences.
3. In the Preferences window, now click on the Sharing tab.
4. This is where you can choose what you'd like to share. You have the option to password protect your library, which we would recommend for when you're on public networks.
5. That's all there is to it. Others will now be able to see your library when it iTunes and stream the files you have chosen to share.

As a side note, newer versions of iTunes tend to hide the sidebar by default, which can make it a little difficult to find. Just go to View in the top menu and click on Show Sidebar to bring it back. This is where you'll see a list of shared libraries when they're available. Apple used to also let you copy music from one library to another as long as both computers were authorized under the same iTunes account. Anyone know why this feature was removed? And if it wasn't, where the heck is it now?

Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/lH8ezBRBcQQ/story01.htm

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Sony E3 2013 PlayStation briefing roundup: PS4 takes E3 with $399 price tag

Finally, the PS4's menacing-looking box has been revealed. More importantly, however, Sony clearly aimed for the Xbox One's throat during its E3 press conference -- especially with software, services and a cheaper retail price. Alongside a friendly policy toward used games and epic title reveals for the PS4, Sony introduced a new PS3 bundle for the fall and more. Get you fix of all the stories from the event by clicking past the break for our full roundup.

Follow all of our E3 2013 coverage at our event hub.

Filed under: Gaming, HD, Sony

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Source: http://www.engadget.com/2013/06/11/sony-e3-2013-playstation-briefing-ps4/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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TRAVEL AND LEISURE: Hongkong and Macau Leisure Trip ...

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Source: http://mfirstnamegatar.blogspot.com/2013/06/travel-and-leisure-hongkong-and-macau.html

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Down 1-0 to Spurs, Heat seek some NBA Finals fun

Miami Heat small forward LeBron James, left, points a video camera at shooting guard Dwyane Wade after a news conference following basketball practice on Saturday, June 8, 2013, at the American Airlines Arena in Miami. The Heat and the San Antonio Spurs are to play Game 2 of the NBA Finals, Sunday. (AP Photo/Wilfredo Lee)

Miami Heat small forward LeBron James, left, points a video camera at shooting guard Dwyane Wade after a news conference following basketball practice on Saturday, June 8, 2013, at the American Airlines Arena in Miami. The Heat and the San Antonio Spurs are to play Game 2 of the NBA Finals, Sunday. (AP Photo/Wilfredo Lee)

Miami Heat small forward LeBron James shoots across the court as he is watched by members of the media during basketball practice on Saturday, June 8, 2013, at the American Airlines Arena in Miami. The Heat and the San Antonio Spurs are to play Game 2 of the NBA Finals, Sunday. (AP Photo/Wilfredo Lee)

San Antonio Spurs point guard Tony Parker, left, of France, talks with head coach Gregg Popovich during basketball practice, Saturday, June 8, 2013, at the American Airlines Arena in Miami. The Miami Heat and the Spurs are to play Game 2 of the NBA Finals, Sunday. (AP Photo/Wilfredo Lee)

San Antonio Spurs guard Manu Ginobili, of Argentina, gestures as he speaks to members of the media before NBA basketball practice, Saturday, June 8, 2013 at the American Airlines Arena in Miami. The Miami Heat and the Spurs play in Game 2 of the NBA Finals on Sunday. (AP Photo/Wilfredo Lee)

San Antonio Spurs point guard Tony Parker, of France, stretches during basketball practice on Saturday, June 8, 2013, at the American Airlines Arena in Miami. The Miami Heat and the Spurs are to play Game 2 of the NBA Finals, Sunday. (AP Photo/Wilfredo Lee)

MIAMI (AP) ? The NBA Finals. Just being here can be memorable ? and miserable.

And surprise, it's those supposedly stoic Spurs who are having more fun, while the South Beach bunch is a little grumpy and grouchy.

The Miami Heat may be on top of the basketball world, but there's no joy unless they stay there.

"Playoffs ain't fun, man. I'm sorry to bust anyone on the outside's bubble," Dwyane Wade said. "As a player in the playoffs, you have no joy until it's over and you won. If you don't win, you have no joy for a while."

Down 1-0 after a record regular season that goes for naught without another title, the Heat can turn their moods around with a victory over San Antonio on Sunday night in Game 2.

Back in the finals for a third straight year, the Heat have lost some of the ability to enjoy the ride. With exorbitant expectations, all that matters is the destination.

But San Antonio, absent from this stage for six years, is soaking up what could be its last shot for Tim Duncan, Tony Parker and Manu Ginobili.

After all, Duncan is pretty ancient ? at least, according to those wise-cracking Spurs.

"Older than dirt," coach Gregg Popovich called him this week.

Parker listed him at age 50 ? Duncan is actually 37 ? and the repeated ribbing appears almost out of character for a franchise that was often considered the definition of basketball blandness.

"My friends and everybody on the team, we get like the funny Instagram doctored-up photos or jokes where they're making fun of how old some of the people on our team are who shall remain nameless," reserve Matt Bonner said. "And we get a kick out of that."

Despite the notion they're old, the Spurs are actually overall the younger, less-experienced team in these finals. Miami has nine players in their 30s to the six on the Spurs, and their Big Three and Bonner are the only Spurs to have played in the NBA Finals.

That makes it easier for the Spurs to enjoy this trip more than when they were the team expected to be here every year.

"We definitely are having fun," Parker said. "I think we appreciate every moment. We don't take anything for granted, because it's been a long time. It's been six years. Felt like forever. After the Memphis series, there was a lot of emotion."

Heat veteran Shane Battier wasn't exactly sold on the notion of this Spurs transformation into a happy-go-lucky group.

"Don't believe them, first of all," he said. "They are extreme competitors and they have a level of self-deprecation I think that is part of them, but don't buy it for one second. Those guys are killers. They're cut-throat and they will stomp on you if need be, and we're the same way.

"We appreciate the opportunity to play in the finals. Difficult to get here. Hardest thing you'll do in this game is to try and win a championship, so we appreciate the opportunity and we want to make the most of it," he said.

But he agreed with Wade that the playoffs aren't fun.

"No, they're not," he said. "They're stimulating. You feel alive. I wouldn't say fun, but there's no other place I'd rather be. It's kind of a misery you enjoy. You're cranky, especially after a loss. You don't like the other team. You're just a general grouch, but it's the time you feel most alive as a basketball player and there's nothing like it. Once you taste it, you don't want to live without it."

It's a grind, though, for a team that will be playing its 100th game of the season Sunday. Wade has battled a painful right knee for a while, Chris Bosh is in a shooting slump, and the minutes are adding up for LeBron James, who has played deep into June the last three years and then competed in the Olympics last year.

"It's a toll for myself to go through what I've been through the last 2? years. But I've been blessed, I've been blessed to be able to be in three finals, I've been blessed to be a part of a great Olympic team and to play basketball, the game that I love," James said.

"I'm not going to be able to do it forever. The opportunities that the game has given me for the last couple of years, I wouldn't substitute that for rest," he said.

James and the Heat at least got some with two days off following the Spurs' 92-88 victory in Game 1. Both James and Wade had mentioned fatigue when talking about Miami's poor fourth-quarter performance, just three nights after the end of a difficult, seven-game series against Indiana to decide the Eastern Conference championship.

The break gave the Heat more time to examine ways their own Big Three can be successful on offense, as well as get some more defensive pressure on the Spurs, who committed just four turnovers ? none by Parker ? in the opener.

"I think it's been great for us, these last I don't know how many hours it's been since Game 1," James said. "But we've used the time, I think, wisely in this case."

They showed up in better spirits Saturday, James and Wade among several players taking part in a post-practice shooting contest, the kind of fun it seemed they would always have from the moment they debuted as Miami teammates three years ago in a welcoming party that rivaled a rock concert.

There will be time for partying if they rally to win the series after a one-game deficit, just as they did last year in the finals. The Heat haven't lost consecutive games in five months, and they know this is no time to start.

"We're not a team that really says too much this is a must-win game, but this is a must-win game for us," Wade said. "We have to win this game at home."

___

Follow Brian Mahoney on Twitter: http://www.twitter.com/Briancmahoney

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-06-08-NBA%20Finals/id-11296e817cba436eb451949d4648aef3

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Booker Formally Announces Senate Bid (ABC News)

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